Table 1 |
|
|
Metabolic changes after major trauma. |
|
| "Ebb" phase (hours) |
"Flow" phase (days to weeks) |
|
|
|
| Decreased body temperature |
Increased body temperature |
| Decreased oxygen consumption |
Increased oxygen consumption |
| Lactate acidosis |
Negative nitrogen balance |
| Increased stress hormone levels |
Increased stress hormone levels |
| Decreased insulin levels |
Normal to increased insulin levels |
| Hyperglycaemia, insulin resistance |
Hyperglycaemia, insulin resistance |
| Gluconeogenesis |
Gluconeogenesis |
| Increased substrate consumption |
Proteinolysis ("autocannibalism") |
| Hepatic acute-phase response |
Lipolysis |
| Immune activation |
Immunosuppression |
|
|
|
|
Hasenboehler et al. World Journal of Emergency Surgery 2006 1:29 doi:10.1186/1749-7922-1-29 |
|
